This case study focuses on Clare Giardini, a 70-year-old woman with a complex medical history including osteoarthritis, non-insulin dependent diabetes, hypertension, systolic dysfunction, and chronic controlled atrial fibrillation, who frequently presents to the hospital with shortness of breath. The report analyzes relevant data for a comprehensive nursing assessment, including her medications (Metformin, Paracetamol, Diclofenac, Quinapril, Furosemide), vital signs, and social history. It identifies contributing factors to her chronic conditions and current health exacerbation, such as medication interactions and lifestyle. The case study emphasizes nursing assessments, interventions, and strategies for effective self-management, including education on nutrition, exercise, and medication adherence. The role of nurses in chronic disease self-management, including patient education and pharmacological assessment, is discussed, alongside primary and secondary health promotion strategies. The study highlights the importance of a multidisciplinary approach and evidence-based interventions to improve Clare's health outcomes, considering her family history and social support.