MCELBIX499.4-060 Hematology Report: RBC Morphology Analysis

This report, focusing on hematology, provides an in-depth analysis of red blood cell (RBC) morphology and associated abnormalities. It begins with an introduction to anemia and the role of RBCs, followed by a discussion of various RBC deformities and their impact. The report emphasizes the importance of grading abnormal RBC morphology based on shape, size, color, and inclusions. It also covers the causes of these abnormalities, including genetic factors, underlying illnesses, and environmental changes, and their clinical consequences, such as the risk of thalassemia, blood loss, hemolysis, and bone marrow failure. The report highlights the significance of careful observation in diagnosing conditions, especially in children, and concludes with a question about the potential of bone marrow transplants as a treatment. References to relevant literature are also included to support the findings.

MCELLBIX499.4-060 HEMATOLOGY 1
MCELlBIX499.4-060 Hematology
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MCELlBIX499.4-060 Hematology
1.Introduction to anemia
There are various types of aberrant RBC morphology. Deformed red blood cells result in a
disorder called anemia. The red blood cell cells are produced in the bone marrow and are
released into the bloodstream. In the bloodstream. They live for about three months before they
are sent to the spleen to be destroyed. If the number of red blood cells is too low, there will be an
abnormally low number of oxygen levels in the tissues, which will result in anemia. This
condition can also occur when the red blood cells are deformed.
2. various red blood cells morphology
Red blood cells could undergo deformities due to multiple reasons. The abnormalities could be
visible o their size, shape or color. The type of morphology can be used to diagnose the diseases
that the patient is suffering. The morphology of red blood cells is observed using a blood smear
and a light microscope (Constantino 2015, p.1-7).
3. Reporting and grading Abnormal red blood cell morphology
Abnormalities in the clinical laboratory have a unique grading system. According to Constantino
(2015, p 1-7), the abnormalities of the red blood cells can be graded based on their shape, size,
color, and inclusions present. The morphology of the deformed red blood cells is used to classify
the abnormality; the first aspect is the shape of the erythrocyte. The red blood cells should be
biconcave shaped; however, abnormal red blood cells can take up a new shape, for example,
sickle shape. Another aspect is the size; an abnormal RBC may be microcytes, macrocytes, or
oval macrocyte. The researcher should observe if there is dual population or anisocytosis. The

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color of the red blood cells can be used to grade the red blood cell. Finally, the inclusions present
in the cell and the surrounding bodies play a role in the grading of red blood cell morphology.
Various molecular mechanisms can cause abnormalities to occur. An example is the genetic
makeup of an individual, presence of underlying illnesses, change in altitude and change in the
climate.
The related clinical consequence of these abnormalities is some diseases increased the risk of
developing thalassemia. Abnormalities may also be an indication of blood loss, hemolysis and
bone marrow failure. The morphology of the red blood cells should be clearly observed before
making a diagnosis, especially in children or infants (Barns 2018, p 52)
Do you think that some abnormalities could be cured using a bone marrow transplant?

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References
Barns, S., 2018. Numerical modeling of red blood cell morphology and deformability (Doctoral
dissertation, Queensland University of Technology). p 52
Constantino, B.T., 2015. Reporting and grading of abnormal red blood cell
morphology. International journal of laboratory hematology, 37(1), pp.1-7.