This report delves into the relationship between Herpes Simplex Virus (HSV) and Alzheimer's disease. It explores the prevalence of HSV, its potential impact on the central nervous system, and its possible link to the development of Alzheimer's. The report discusses research findings, including the detection of HSV in Alzheimer's patients' brains and the role of the APOE-e4 allele. It examines the pathogenesis of Alzheimer's disease, focusing on the amyloid-β precursor protein (APP) and its interaction with HSV. The report highlights how HSV infection affects APP processing, distribution, and transport, potentially leading to cellular damage and the formation of neurofibrillary tangles. Furthermore, it suggests that antiviral strategies may be effective in slowing or preventing the progression of Alzheimer's disease, emphasizing the need for clinical trials to evaluate the efficacy of antiviral medications.