This presentation provides a comprehensive overview of high blood pressure, a cardiovascular disorder. It begins with a brief exploration of the normal physiology of the heart, including its structure, plumbing, and electrical system, emphasizing the chambers and their functions. The presentation then delves into the pathophysiology of hypertension, highlighting atherosclerosis as a major cause, detailing associated risk factors like smoking, hypertension, and hypercholesterolemia, and explaining the mechanisms behind fatty fibrous lesions. Furthermore, it discusses the pharmacology of hypertension, including diuretics, ACE inhibitors, their mechanisms, and their clinical implications, such as benefits, side effects, and considerations for specific patient groups. The presentation concludes by emphasizing the importance of evidence-based practices in preventing cardiovascular disease and the role of cardiologists in implementing the latest treatments to achieve therapeutic goals. References to support the information are included.