Hormone Replacement Therapy in Healthcare: A Detailed Overview

This report provides a comprehensive overview of Hormone Replacement Therapy (HRT) in healthcare, focusing on the risks, benefits, and side effects associated with its use in menopausal women. The report begins by defining menopause and the various hormonal and non-hormonal therapies available, including estrogen, progesterone, and other treatments. It highlights the prevalence of menopause-related symptoms and the fluctuating hormone levels during perimenopause. The report then discusses the potential advantages of HRT, such as the prevention of osteoporosis and reduced risk of heart disease, while also addressing the disadvantages, including the increased risk of certain cancers and blood clots. It emphasizes that the initiation of HRT within a decade of menopause has been found to be more consistent than later initiation. The conclusion underscores the importance of HRT in managing menopausal symptoms and the need to carefully consider both the short-term and long-term risks and benefits for each patient.

Running head: HORMONE REPLACEMENT THERAPY IN HEALTHCARE
TOPIC: HORMONE REPLACEMENT THERAPY IN HEALTHCARE
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1HORMONE REPLACEMENT THERAPY IN HEALTHCARE
This report is an account of the various risks which is involved in women after changes in
hormonal levels after menopause. Menopause has been a common term associated with the
permanent stoppage of menstrual cycle after midlife or in older women. There are various
therapies included for the convenience of menopausal women. Hormone replacement therapy
is one such method. The following paragraphs will encompass the various risks involve with
the hormonal replacement therapies and the various side effects associated with it alongside
the potential advantages and disadvantages of the mentioned therapy.
Menopause is actually the time period when there is cessation of the menstrual cycle
permanently as a result of the depletion of the ovarian oocytes as a result of aging. This kind
of diagnoses is retrospective of the time women stop having their normal menstrual cycles
from 12 months of the first stoppage. It thus is a mark of end of permanent fertility and the
average age of menopause is usually 51 years. There are various hormonal as well as non-
hormonal therapies. Hormonal therapies include estrogens, progesterone, androgens and
tibolone. Non hormonal theories are inclusive of anticonvulsants, anti-hypertensive s like
clonidine, acupuncture methods, sedatives and soy and herbal supplements. According to
statistics, menopause elated systems pertaining to the genitourinary system affect more than
50% of older women and midlife. Moreover, such statistics vary according to various
countries. In Australia, prevalence of early menopause was 4% whopping to 25% after one
year after menopause as well as 47%, after 3 years after menopause (Portman, Gass and
Vulvovaginal Atrophy Terminology Consensus Conference Panel 2014).
Perimenopause is often followed by fluctuating as well as declining levels of estrogen.
Moreover, there is also varying levels of other steroid hormones which stimulate the
synthesis of various neurotransmitters. In addition there also has been declining levels of
serotonin as well as norepinephrine. One of the important risks is the depressive symptoms
which occur in menopausal transition for women (Dalal and Agarwal 2015).

2HORMONE REPLACEMENT THERAPY IN HEALTHCARE
The hormone replacement theory has been suggested for women and has proved to be
beneficial for osteoporosis, dementia, coronary heart disease as well as all cause mortality
prevention. It has been used as a recommendation by the physicians for advocating HRT as a
prevention strategy. Newer findings suggest that women at the initiation of HRT with a
decade are much consistent than women who have undergone HRT at the time of menopause
(Utian and Schiff 2018).
Though HRT has become a common form of treatment, there are various side effects
associated with it. Although many of the adverse effects are not life threating some of them
include symptoms like tenderness of the breast, bleeding of the uterus, bloating of the
abdomen occasional mood swings. Other serious consequences involve venous
thromboembolism, and increasing cases of risks of cancer. It has been found that such
symptoms are associated with a special type of oestrogen (Lobo 2017).
Contraindications of HRT include uterine bleeding which is often uncontrolled and
irregular, untreated hyperplasia of the endometrium, coronary heart diseases of earlier cases,
followed by dementia, stroke, active diseases of the liver in excess amounts, ostosclerosis,
and finally denial through personal reasons. Conditions which are not contraindications
include gynecological cancers, as well as cervical carcinomas, hypertension,
hypertriglyceridemia. Smoking may not be included under contraindications, but they may
led to strict personalization inclusive of doses as well route of administration and
transdermal preparations (Gammbacianni et al. 2018).
As far as the potential advantages as well as disadvantages of Hormone regulated therapy
is concerned, doses of only estrogens are required for women who have undergone
hysterectomy. Thus it has fund that hormones do not have positive signs and symptoms when

3HORMONE REPLACEMENT THERAPY IN HEALTHCARE
consumed for a prolonged period of time. Instead HRT is a better method treatment for
menopause symptoms for an instance hot flashes for even the lowest possible dose.
The various advantages include prevention of diseases like osteoporosis, and reduced
chances of fracture, increased chances of sleep and rest, eased dryness of the vagina as well
as itching, reduced chances of having heart diseases as well much lower chances of being
affected with dementia.
There are various disadvantages of hormone replacement theory, development of breast
cancer being the most important cause. Moreover after a prolonged treatment through HRT,
there are increased chances of blood clots and heat strokes.
Thus it can be concluded from the following paragraphs that Hormone replacement theory
has an important role to play in the reduction cases of women suffering from menopauses
which is subsequently followed by reduced amounts of the corticosteroids and related
hormones, primarily estrogen as well as progesterone. There are some long term as well as
short term risks associated with the theory which will prove beneficial in the future.

4HORMONE REPLACEMENT THERAPY IN HEALTHCARE
References
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