This dissertation delves into the critical topic of sterilization procedures, specifically focusing on hydrogels used in healthcare, particularly for wound healing. The research encompasses various sterilization methods, including moist heat, dry heat, liquid chemical, toxic gas, and radiation sterilization, with a detailed examination of their effectiveness and suitability for hydrogel materials. The study identifies the importance of sterilization in eliminating pathogens and preventing infections associated with medical devices. Furthermore, the dissertation explores the current Good Manufacturing Practices (GMP) and Australian guidelines relevant to the production of hydrogel wound dressings, ensuring the safety and efficacy of these devices. The methodology involves a systematic review of literature, including question formulation, inclusion/exclusion criteria, literature search, data extraction, and quality appraisal. The results section presents detailed information on sterilization methods, hydrogel properties, and the therapeutic goods administration guidelines. The dissertation concludes with recommendations, acknowledging limitations, and emphasizing the need for appropriate sterilization procedures to minimize wound infection rates and improve patient outcomes.
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