This report provides a comprehensive overview of hypercholesterolemia, a prevalent condition marked by elevated levels of LDL cholesterol, detailing its pathophysiology and the associated risks of cardiovascular disease. The report explains how the accumulation of lipids leads to atherosclerosis and its complications, including ischemic events. It then explores the pharmacology of Lovastatin, a statin drug, focusing on its mechanism of action in reducing LDL cholesterol levels by inhibiting HMG-CoA reductase. The report also discusses the clinical use of Lovastatin, its effectiveness in lowering LDL levels, and the potential adverse effects. It highlights the importance of statins in managing hypercholesterolemia and reducing the risk of cardiovascular events, concluding with a summary of the disease, its treatment, and the role of Lovastatin. The report includes the pathophysiology of the disease, the risk factors, and the pharmacology of the medicines used to treat the disease.