This report delves into the significant impacts of the COVID-19 pandemic and Brexit on International Human Resource Management (IHRM) within multinational enterprises (MNEs). It explores how these external factors have reshaped global work, emphasizing the use of global teams, virtual collaboration, and international assignments. The report analyzes the effects of the pandemic on MNEs, including supply chain disruptions, financial challenges, and changes in foreign direct investments. It also examines the impact of Brexit, particularly on supply chains and the relocation of headquarters. Furthermore, the report investigates how COVID-19 has influenced IHRM practices, such as remote work, employee well-being, and the role of HR in managing crises. The report also discusses strategies for IHRM to handle the crisis, including selection, training, and support for employees, along with the importance of health and safety measures. The report concludes by highlighting the need for MNEs to adapt to new market conditions and embrace technological innovations to overcome challenges and seize opportunities.