This dissertation delves into the profound impact of the HIV/AIDS pandemic on the health systems of South Africa and Zimbabwe, examining the right to health within the context of the International Covenant on Economic, Social and Cultural Rights (ICESCR). The study investigates the prevalence of HIV/AIDS, its drivers, and the challenges faced by healthcare systems in both countries. It analyzes national health policies, programs, and the influence of political and economic factors on the prevention, treatment, and delivery of care. The research explores the research gap by examining the correlation between HIV/AIDS burden and delivery of care by healthcare systems. The dissertation examines the human rights implications, including stigma and discrimination, and their impact on access to healthcare. The methodology includes secondary research. The findings, results and discussion of the dissertation highlight gender inequality, human rights abuses, economic challenges, and ineffective policy implementation. The dissertation concludes with recommendations for behavioral, biomedical, and structural interventions to improve HIV/AIDS management and mitigate the pandemic's impact. It aims to provide insights into strengthening healthcare systems and promoting human rights to improve the health and well-being of the populations in South Africa and Zimbabwe.