This essay critically evaluates the concept of 'failure to rescue' in the context of acute healthcare, focusing on the deteriorating patient. It begins with a definition of failure to rescue and examines its incidence and consequences, including impacts on patients, their families, and the healthcare system, referencing statistics on adverse events in Australian hospitals. The essay then discusses environmental and educational barriers faced by nurses in preventing failure to rescue, such as low nurse-to-patient ratios and insufficient training. It explores strategies to overcome these barriers, including simulation-based training and continuous vital sign surveillance systems. The essay also highlights nursing strategies like clinical autonomy and interprofessional practice to enhance patient safety, emphasizing the importance of nursing knowledge and teamwork in improving patient outcomes. The analysis is underpinned by a focus on patient safety and includes interprofessional practice to prevent adverse events.