This essay delves into the international human resource management (IHRM) issues that arose from Johnson & Johnson's acquisition of Actelion. The analysis examines the challenges related to employee selection, attrition, and cross-cultural communication within the newly formed firm, Idorsia. The essay highlights how power politics and a lack of expertise in management roles contributed to IHRM issues, impacting the firm's profitability and employee morale. Furthermore, it explores how differing organizational cultures between Johnson & Johnson and Actelion created intercultural issues, affecting employee performance and workplace dynamics. The essay provides a comprehensive overview of the IHRM challenges faced during the cross-border merger and acquisition, offering insights into the importance of effective HRM practices in such scenarios.