La Trobe University CSE5BIO: Bioinformatics Technologies Assignment

This document provides a comprehensive solution to a bioinformatics assignment focusing on fundamental concepts and practical applications. It begins with an overview of the central dogma of life, explaining the roles of DNA, RNA, and proteins in protein synthesis. The solution then lists and describes primary sequence databases (GenBank, EMBL, UniProtKB), protein structure databases (PDB, SCOPe, CATH/Gene3D), and genome databases (MaizeGDB, OMIM, Ensembl), including their respective URLs. The assignment further involves investigating the Myosin VI gene in Homo sapiens using the NCBI Gene Database, detailing its function, major pathways, and exon count. The protein sequence is then extracted, and its 3D structure is generated using the Swiss-Model server. Finally, the report from Swiss-Model is analyzed to identify the template used in building the model and provide the sequence alignment of the target and the template. This solved assignment is available on Desklib, a platform offering a wealth of study resources including past papers and solved assignments for students.