Chemical Engineering Analysis: Lactose Powder Properties and Tableting

This report provides a detailed analysis of the physical properties of lactose powder and their significant impact on granulation and tableting behavior in pharmaceutical manufacturing. It explores the differences between α- and β-lactose isomers, highlighting their effects on solubility, crystallization, and morphology. The report discusses characterization tests such as HPLC, spectrophotometry, and electrochemical methods, along with particle properties like powder flow and density, and the importance of optimized manufacturing systems to reduce batch failures. It also addresses the issue of triboelectrification, which causes particle segregation, and proposes measures to minimize it, including improvements in material properties and the use of electrostatic force to control particle movement. The report concludes with recommendations to control particle electrification during processing, emphasizing the importance of these methods for various industrial systems.