This essay delves into the critical relationship between leadership styles and patient safety within healthcare environments. It begins by defining leadership and patient safety, establishing their interconnectedness, and emphasizing the importance of leadership in ensuring patient well-being. The essay then explores two prominent leadership styles: transformational and transactional leadership. Transformational leadership is presented as a style that fosters positive organizational developments by involving subordinates, creating awareness of rewards, and promoting long-range ambition and trust. The essay discusses how transformational leaders empower nurses and focus on cultural impacts to enhance patient safety. Conversely, transactional leadership is described as an exchange-based approach where leaders clarify objectives, reward achievements, and correct errors. The essay highlights how transactional leaders promote patient safety by engaging families, creating safe practices, and ensuring proper medication prescriptions. The conclusion reinforces the significance of patient safety in nursing care and underscores the role of various leadership styles in promoting excellent services and safe care within healthcare settings, referencing relevant literature.