This essay explores the critical role of leadership styles in influencing patient safety within healthcare settings, particularly focusing on the impact of nurse leaders. It examines three primary leadership styles: transformational, transactional, and laissez-faire, analyzing their respective effects on patient outcomes, including medication errors, patient falls, and hospital-acquired infections. The essay highlights that transformational leadership, characterized by inspiring and motivating followers, is strongly associated with improved safety and reduced adverse events, such as lower mortality rates and fewer medication errors. Conversely, it finds that laissez-faire leadership, with its lack of direction and supervision, negatively impacts patient safety. Transactional leadership's effectiveness is also considered, with the understanding that it can be beneficial when leaders set clear expectations and monitor performance to ensure adherence to safety guidelines. The conclusion emphasizes the importance of nurse leaders selecting the most appropriate leadership style to foster a culture of safety, ultimately improving patient care.