This essay delves into the critical role of leadership styles in ensuring patient safety within healthcare settings. It contrasts transformational and transactional leadership approaches, highlighting their respective impacts on organizational culture, employee satisfaction, and patient outcomes. Transformational leadership is presented as a method that strengthens staff comprehension, justice, and improves the quality of life in an organization, leading to improved healthcare quality and reduced medication errors for deteriorating patients. The essay also examines the transactional leadership style, focusing on its emphasis on performance, structure, and short-term goals, as well as its potential limitations in fostering long-term relationships and innovation. The conclusion emphasizes the need for effective leadership to maintain high-quality care systems and promote patient safety. The references include several academic sources that support the arguments presented.