Comprehensive Literature Review: Clinical Trials and Drug Research

This document presents a literature review focusing on various aspects of drug trials and clinical research. It includes an analysis of multiple scholarly articles and research papers, covering topics such as gene therapy, pain management, nursing research, and the development of new drugs. The review examines the methodologies used in clinical trials, the outcomes of different studies, and the challenges faced in the field of drug development. Several key publications are cited and analyzed, offering insights into the current state of research and future directions. This literature review provides a comprehensive overview of the topic, highlighting significant findings and trends within the healthcare and research domains.

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1 Google
Scholar
Ayt
on, L.N.,
Blamey, P.J.,
Guymer,
R.H., Luu,
C.D.,
Nayagam,
D.A.,
Sinclair,
N.C.,
Shivdasani,
M.N., Yeoh,
J.,
McCombe,
M.F., Briggs,
R.J. and
Opie, N.L.,
2014. First-
in-human
trial of a
novel
suprachoroi
dal retinal
prosthesis.
PloS one,
9(12), pp.
115-239.
http://
journals.plo
s.org/
plosone/
article?
id=10.1371/
journal.pon
e.0115239
Human
Drug trials
1,350,000
(2010-2018)
19
2 Google
Scholar
Ginn, S.L.,
Alexander,
I.E.,
Edelstein,
M.L., Abedi,
M.R. and
Wixon, J.,
2013. Gene
therapy
clinical trials
worldwide
to 2012–an
update. The
journal of
gene
medicine,
15(2),
pp.65-77.
https://
avestia.com
/
NewTech20
16_Proceedi
ngs/files/
paper/
ICBB/
112.pdf
Gene
Therapy
2,170,000 116

3 Google
Scholar
Inoue, H.,
Nagata, N.,
Kurokawa,
H. and
Yamanaka,
S., 2014. iPS
cells: a
game
changer for
future
medicine.
The EMBO
journal,
33(5),
pp.409-417.
https://
www.ncbi.n
lm.nih.gov/
pubmed/
24500035
Human
beings and
drug trials
18400
4 Google
Scholar
Barr, J.,
Fraser, G.L.,
Puntillo, K.,
Ely, E.W.,
Gélinas, C.,
Dasta, J.F.,
Davidson,
J.E., Devlin,
J.W., Kress,
J.P., Joffe,
A.M. and
Coursin,
D.B., 2013.
Clinical
practice
guidelines
for the
managemen
t of pain,
agitation,
and
delirium in
adult
patients in
the
intensive
care unit.
Critical care
medicine,
41(1),
pp.263-306.
https://
www.ncbi.n
lm.nih.gov/
pubmed/
23269131
Pain
managemen
t for drug
trials
225,000 13
5 Google Loren, A.W., 94600 14

Scholar Mangu,
P.B., Beck,
L.N.,
Brennan, L.,
Magdalinski
, A.J.,
Partridge,
A.H., Quinn,
G., Wallace,
W.H. and
Oktay, K.,
2013.
Fertility
preservatio
n for
patients
with cancer:
American
Society of
Clinical
Oncology
clinical
practice
guideline
update.
Journal of
Clinical
Oncology,
31(19),
p.2500.
https://
www.ncbi.n
lm.nih.gov/
pubmed/
23715580
Pain
managemen
t among
women
6 Google
Scholar
Zhou, C.,
Wu, Y.L.,
Chen, G.,
Feng, J., Liu,
X.Q., Wang,
C., Zhang,
S., Wang, J.,
Zhou, S.,
Ren, S. and
Lu, S., 2011.
Erlotinib
versus
chemothera
py as first-
line
treatment
for patients
https://
www.ncbi.n
lm.nih.gov/
pubmed/?
linkname=p
ubmed_pub
med&from_
uid=261056
00
EGFR
mutation
6240 12

with
advanced
EGFR
mutation-
positive
non-small-
cell lung
cancer
(OPTIMAL,
CTONG-
0802): a
multicentre,
open-label,
randomised
, phase 3
study. The
lancet
oncology,
12(8),
pp.735-742.
Google
Scholar
Houser, J.,
2013.
Nursing
research:
Reading,
using and
creating
evidence.
Jones &
Bartlett
Publishers.
https://
www.amazo
n.com/
Nursing-
Research-
Reading-
Creating-
Evidence/
dp/
1284043290
Nursing
research
32800 8
7 Google
Scholar
Hammersle
y, M., 2016.
Reading
ethnographi
c research.
Routledge.
http://
journals.sag
epub.com/
doi/
10.1177/00
3803859002
4004003
Virtual
research
methods
15800 3
8 Google
Scholar
Faden, R.R.,
Kass, N.E.,
Goodman,
S.N.,
Pronovost,
P., Tunis, S.
and
Beauchamp,
https://
www.ncbi.n
lm.nih.gov/
pubmed/
23315888
Future
medicine
395 2

T.L., 2013.
An ethics
framework
for a
learning
health care
system: a
departure
from
traditional
research
ethics and
clinical
ethics.
Hastings
Center
Report,
43(s1).
9 Google
Scholar
Fain, J.A.,
2017.
Reading,
understandi
ng, and
applying
nursing
research. FA
Davis.
https://
www.amazo
n.com/
Reading-
Understandi
ng-
Applying-
Nursing-
Research/
dp/
0803660413
Applying
nursing
research in
real wordl
326 3
10 Google
Scholar
Denscombe,
M., 2014.
The good
research
guide: for
small-scale
social
research
projects.
McGraw-Hill
Education
(UK).
http://
www.acade
mia.edu/
2240154/
The_Good_
Research_G
uide_5th_e
dition_
Research
Guide
10,900 2
11 Google
Scholar
Bowling, A.,
2014.
Research
methods in
https://
www.amazo
n.com/
Research-
Reserch
methods
42,600 4

health:
investigatin
g health and
health
services.
McGraw-Hill
Education
(UK).
Methods-
Health-
Investigatin
g-Services/
dp/
0335233643
12 Google
Scholar
Husereau,
D.,
Drummond,
M., Petrou,
S., Carswell,
C., Moher,
D.,
Greenberg,
D.,
Augustovski
, F., Briggs,
A.H.,
Mauskopf,
J. and
Loder, E.,
2013.
Consolidate
d health
economic
evaluation
reporting
standards
(CHEERS)—
explanation
and
elaboration:
a report of
the ISPOR
health
economic
evaluation
publication
guidelines
good
reporting
practices
task force.
Value in
Health,
https://
www.ncbi.n
lm.nih.gov/
pubmed/
23538175
Economic
health
evaluation
495 2

16(2),
pp.231-250.
13 Google
Scholar
Schneider,
L.S.,
Mangialasch
e, F.,
Andreasen,
N.,
Feldman,
H.,
Giacobini,
E., Jones, R.,
Mantua, V.,
Mecocci, P.,
Pani, L.,
Winblad, B.
and
Kivipelto,
M., 2014.
Clinical
trials and
late-stage
drug
developmen
t for
Alzheimer's
disease: an
appraisal
from 1984
to 2014.
Journal of
internal
medicine,
275(3),
pp.251-283.
https://
www.ncbi.n
lm.nih.gov/
pubmed/
24605808
Drug trials 557 3