This assignment presents a literature review and critical thinking exercise based on a randomized controlled trial (RCT) examining the effectiveness of soft silicone multi-layered foam dressings in preventing sacral and heel pressure ulcers in trauma and critically ill patients (the Border Trial). The assignment identifies the independent and dependent variables, PICO components (Patient, Intervention, Comparison, Outcome), and determines the study's experimental design. It explores the use of randomness and blinding in the study, the statistical tests employed (Fisher's Exact Test), and the significance of the results. The review also discusses the potential clinical implications of the findings, such as the benefits of silicone dressings in reducing hospital stays. The assignment references the original research paper by Santamaria et al. (2013) and summarizes the findings and analysis performed, providing a comprehensive overview of the study's methodology and conclusions. The assignment uses the provided assignment brief which details the course information and context for the assignment.