BHS104A: Lymphatic System: T-cell and B-cell Maturation Process

This presentation provides an overview of the lymphatic system, focusing on the maturation and activation processes of T-cells and B-cells. It begins by outlining the components of the lymphatic system, including lymphatic vessels, lymph, lymphoid tissue, and lymphoid organs, and their crucial roles in immune responses, fluid balance, and lipid transport. The presentation then delves into the specific organs involved in T-cell and B-cell maturation, namely the thymus and red bone marrow, highlighting their respective functions in lymphocyte development. The core of the presentation examines the distinct characteristics and functions of T-cells (CD8 and CD4) and B-cells, including their roles in adaptive immunity, antibody production, and antigen recognition. It explains the maturation and activation pathways of both cell types, including the roles of accessory molecules and cytokines. The presentation concludes by emphasizing the complexity and importance of T-cell and B-cell maturation for effective immune responses, supported by references to key research articles and textbooks. This resource is available on Desklib, a platform providing students with essential AI-based study tools including past papers and solved assignments.

Lymphatic system
physiological process
– maturation of T-
cells & B- cells
Assessment 2
BHS104A
Lisa Chivers
Brigette Valencia Cein Ibrahim
00274007T

Overview
 Lymphatic system provide defense mechanisms 
carries out immune responses
 Organs  thymus, RBM
 T-cells
 B-cells
 How T – cells & B - cells works together
 Conclusion
 References

Lymphatic system
• Lymphatic system consist of :
• Lymphatic vessels
• Lymph  a transparent, amber-tinted fluid
• Lymphoid tissue
• Lymphoid organs
• 3 functions :
• Drains excess interstitial fluid
• Transport dietary lipids
• Carries out immune responses  defense mechanisms
(Tortora & Derrickson, 2014, p. 800)

Organs related to maturation of T &
B cells
 organs of the immune system consist of :
Thymus
Located in the mediastinum (middle chest cavity)
Instructs immature T- Lymphocytes
Red bone Marrow
 source of red and white blood cells in adults.
Development/maturation of lymphocytes
Important site for B – lymphocyte  antibody production
(Rhoades & Pflanzer, 2003, p.852)

T Cells
• Doesn’t secrete antibody
• Acts as adaptive immune response
• 2 types of T-cells :
• CD8 T- cell  Killer T- cells
• CD4 T-cell  Helper T- cells

B cells
• Primarily produced antibodies
• Fight against extracellular pathogens
• Bind with specific pathogens associate molecules  antigens

B cells maturation and activation
• Negative selection of immature B cells
• Selected cells deleted through apoptosis
• B cells are activated when antigen binds to
receptor
• B cell engulfs antigen
(Wang et al. 2019, p. 86)
Title: How the t and B cells work together
(Source: Liu et al. 2015, p. 2014)

T cells maturation and activation
• T cell maturation receptor is associated with
accessory molecules
• T cells migrate to thymus transforming to CD4
CD8
• T cells mobilized in encounter with dendritic cell
• Cytokines help T cell to mature
• MHC antigen activates T cell receptor
(Ali et al. 2016, p.
1689)
Title: How the t and B cells work together
(Source: Liu et al. 2015, p. 2014)

Conclusion
• Maturation and activation of immunity cells (T and B cells) is complex
• The maturation is highly guided by series of accessory molecules
• A combination of both the cells can help in better immune response

References
• Rhoades, R., & Pflanzer, R. (2003). Human physiology (4th ed.). Pacific Grove, Calif.: Brooks/Cole.
• Tortora, G., & Derrickson, B. (2014). Principles of anatomy & physiology. (14th ed.). USA:Wiley
• Peate, I., & Nair, M. (2016). Fundamentals of anatomy and physiology: For nursing and healthcare
students. (2nd ed.). UK:John Wiley & Sons, Incorporated
• Wang, Y., Huang, H., Yao, S., Li, G., Xu, C., Ye, Y., & Gui, S. (2019). A lipid-soluble extract of
Pinellia pedatisecta Schott enhances antitumor T cell responses by restoring tumor-associated
dendritic cell activation and maturation. Journal of ethnopharmacology, 111980.
• Ali, S. A., Shi, V., Maric, I., Wang, M., Stroncek, D. F., Rose, J. J., ... & Fellowes, V. S. (2016). T
cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of
multiple myeloma. Blood, 128(13), 1688-1700.
• Liu, D., Xu, H., Shih, C., Wan, Z., Ma, X., Ma, W., ... & Qi, H. (2015). T–B-cell entanglement and
ICOSL-driven feed-forward regulation of germinal centre reaction. Nature, 517(7533), 214.