This report provides an in-depth analysis of alcohol and substance abuse programs, focusing on various aspects such as program descriptions, ethical considerations, risk identification and management, and quality and safety measures. The report begins with an executive summary outlining the differences between substance abuse and addiction, common substances of abuse, and the impact of alcohol. It then delves into the establishment of drug abuse programs, their mission and vision, and the ethical considerations that govern them, including principles like autonomy, justice, beneficence, fidelity, and nonmaleficence. The report further explores risk identification and management strategies, emphasizing the importance of prevention and intervention. Finally, it examines the quality and safety of alcohol and substance abuse programs, including the role of national standards and improvement initiatives like NIATx. The report concludes by highlighting the global significance of the issue and the need for comprehensive approaches to address it.