This report presents a clinical practice improvement project focused on reducing and preventing medication errors by nurses in acute care settings. The project's aim is to analyze medication errors, identify their causes, and implement interventions for improvement. The report highlights the significance of the issue, emphasizing the impact of medication errors on patient safety, healthcare costs, and the healthcare team. Clinical governance is discussed as a crucial framework for improving care quality. Key stakeholders, including healthcare professionals, service users, and leaders, are identified. The cause and effect (fishbone) diagram is selected as the CPI tool to analyze the root causes of medication errors. The report proposes interventions like the Clinical Decision Support System (CDSS) to enhance medication safety and improve patient outcomes. The report emphasizes the importance of staff awareness and responsibility in creating a safer patient environment.