This report presents a comprehensive mental health assessment of a 41-year-old female, Mary, diagnosed with depression. It begins with a holistic assessment, including a mental status examination covering appearance, speech, mood, form and content of thought, perception, sensorium, cognition, and risk assessment. A clinical formulation table summarizes presenting, precipitating, predisposing, perpetuating, and protective factors. A detailed nursing care plan outlines priority interventions, including non-pharmacological strategies, therapeutic relationships, and sleep management, alongside long-term interventions such as a Mental Health Care Plan and potential involuntary treatment orders. An SBAR handover report is provided for effective communication. Part 2 focuses on therapeutic engagement, detailing strategies to develop a therapeutic relationship with Mary and explaining how these strategies relate to the recovery model in mental health. Challenges in working with Mary and the difficulties in primary care settings are also discussed, offering a comprehensive analysis of the case.