This case study delves into the mental health challenges faced by Lisa, examining the impact of trauma, substance abuse, and the application of Trauma-Informed Care Principles (TICP). The analysis identifies key issues, including lack of support, medication non-compliance, and substance abuse relapse, and connects them to TICP principles. It emphasizes the importance of collaborative care involving a multidisciplinary team, family members, and the patient. The study also highlights the benefits of a recovery-oriented model and the application of TICP principles to empower Lisa, provide support, and promote safety and awareness. The case study concludes by underscoring the importance of addressing mental health concerns through effective interventions and support systems, with references to relevant research on mental health, trauma, and substance abuse treatment.