This essay presents a comprehensive case study on mental health nursing within a general hospital setting, focusing on the provision of holistic care to patients with co-morbid physical and mental health conditions. The essay addresses key aspects of nursing practice, including the importance of holistic care, risk assessment (suicide and depression), and the interconnectedness of mental and physical health. The case study involves a registered nurse, Tim, and his approach to patient care, including assessing patients admitted to the general ward. The essay explores the assessment of patients, including the evaluation of both physical and mental health conditions, and highlights the impact of mental health on physical well-being. It also discusses the recognition of psychiatric symptoms, the prioritization of suicide risk assessment, and the differentiation between anxiety and depression. Early diagnosis and the use of questionnaires are also highlighted. The essay emphasizes the importance of early diagnosis, care plans and appropriate interventions for patients. The essay utilizes academic references to support the discussions and findings.