This project proposal outlines the application of virtual clinical trials using the Simcyp simulator to optimize Meropenem usage in pediatric antimicrobial treatments. The project begins by introducing Simcyp as a tool for simulating drug absorption and behavior, emphasizing its benefits and functionality. It then focuses on Meropenem, a carbapenem antibiotic, detailing its properties, mechanism of action, and clinical uses. The proposal includes a review of existing clinical studies to validate the model, focusing on plasma concentration profiles. Furthermore, the project addresses the need for optimized dosage regimens, drug interactions, and potential complications associated with Meropenem, such as interactions with phenytoin and adverse reactions. The project aims to simulate and analyze Meropenem's pharmacokinetic and pharmacodynamic properties in a virtual pediatric population, ultimately providing insights to improve treatment outcomes and minimize risks.
![[object Object]](/_next/static/media/star-bottom.7253800d.svg)
