This systematic review, published in Nursing Research, examines the facilitators and barriers to blood donation within minority populations in the United States. The study, conducted using various electronic databases, employed a meta-synthesis approach to analyze 15 articles and identify key themes. The findings highlight the complex interplay of factors influencing donation, including the impact of knowing a blood recipient, cultural and religious affiliations, and medical mistrust. The review emphasizes the need for community education and communication to rebuild trust and address the underrepresentation of minorities among blood donors, particularly crucial for individuals with sickle cell disease and thalassemia. The research recommends strategies to increase blood donations within minority communities.