This laboratory report investigates sex differences in Nanoblock assembly performance. The study involved 25 participants (14 males, 11 females) divided into groups with and without instructions for assembling Nanoblock models. The experiment measured assembly time and quality, utilizing ANOVA and t-tests for analysis. Results indicated that males generally performed better, completing the task faster and with higher quality, regardless of instruction availability. A significant interaction between gender and instruction was observed, highlighting the influence of both factors on task performance. The report explores the implications of these findings, connecting them to cognitive and spatial abilities, and discusses the observed differences in performance. The study aimed to assess the influence of instructions and gender on the time taken to complete the Nanoblock models. The study also compared the quality of work completed by both genders with and without instructions. The analysis revealed that males performed better than females in terms of time and quality, and the interaction effect between gender and instruction was statistically significant. The report concludes by discussing the observed differences in performance.