This report focuses on evidence-based nursing practice concerning hand hygiene in acute care settings. It begins by highlighting the significance of the issue, emphasizing the high rates of hospital-acquired infections and the need for improved hand hygiene compliance among healthcare professionals and visitors. The report utilizes the PICO framework to formulate a searchable question and synthesizes evidence from five research articles, including systematic reviews and quasi-experimental studies. The analysis of the literature reveals the importance of hand washing in preventing infections and the need for interventional strategies. The report then provides specific recommendations for practice, such as implementing multi-layered hand washing interventions, raising awareness of hand hygiene policies, and using visual aids. The conclusion reiterates the importance of evidence-based hand hygiene practices in reducing infection rates and improving the quality of care in acute care units.