This paper presents a literature review and PICOT statement focusing on the clinical issue of nurse-patient ratio and its impact on patient outcomes. The PICOT statement addresses whether patient outcomes improve in healthcare settings with low nurse-patient ratios compared to high ratios over six months. The review analyzes several articles, exploring the correlation between nurse staffing levels and patient mortality and morbidity in intensive care units, the effect of nurse-patient ratios on neonatal outcomes, and the association between nurse staffing and quality of care. While some studies show inconclusive results, the majority indicate that increased nurse staffing leads to improved patient outcomes, reduced mortality rates, and shorter hospital stays. The review concludes that improving nurse-patient ratios in healthcare settings is likely to result in positive health outcomes.