This assignment solution addresses Evidence for Nursing Assessment 1, focusing on developing a PICO question and search strategy based on a clinical case scenario related to depression. The student utilizes the PICO framework (Patient/Problem, Intervention, Comparison, Outcome) to formulate a structured question and identify relevant search terms. A detailed systematic search plan is created using Boolean operators (AND, OR) to refine the search in the Embase database. The student outlines inclusion criteria and provides a screenshot of their Embase search, demonstrating their ability to translate the search strategy into a database query. The assignment aims to evaluate the student's understanding of evidence-based practice, systematic literature searching, and the application of the PICO framework in a clinical context.