This report presents a comprehensive nursing care plan for Frank Wright, a 76-year-old male who underwent a total knee replacement. The analysis begins with a post-operative assessment, including vital signs and pain levels, and identifies three key clinical issues: hypotension, pain management, and the risk of deep vein thrombosis (DVT). The report then prioritizes nursing interventions, such as periarticular multimodal drug injections, addressing hypotension with ACE inhibitors, and DVT prophylaxis with compression stockings and aspirin, supported by evidence-based rationales. Furthermore, the report explores potential clinical issues related to Frank's co-morbidities, including obstructive sleep apnea (OSA), hypertension, and smoking habits, and their impact on anesthesia and post-operative recovery. The report concludes with a detailed discharge plan, providing instructions on medication management, smoking cessation, physical therapy, and the use of assistive devices to ensure optimal patient outcomes. The study highlights the importance of thorough assessment, proactive intervention, and patient education in providing effective post-operative care.