This report examines the critical role of nursing documentation in ensuring medication safety within the Australian healthcare system, guided by the National Safety and Quality Health Service Standards (NSQHS). The review explores the evolution of health information technology (HIT), including Electronic Health Records (EHRs) and Computerized Physician Order Entry (CPOE), as tools for improving documentation practices and patient outcomes. The literature review synthesizes findings on the impact of HIT on medication error reduction, the effectiveness of CPOE in clinical practice, and the challenges related to patient information privacy and confidentiality. The analysis highlights the importance of integrating nursing perspectives in the design and implementation of HIT systems to optimize usability and address potential issues. The review emphasizes the need for comprehensive training of nursing professionals in the effective use of HIT for documentation and critical thinking, ultimately aiming to enhance the quality of patient care and minimize adverse drug events. The report concludes with the implications of the clinical practice, reinforcing the need for multidisciplinary teamwork and effective communication to improve documentation processes and ensure medication safety.