This essay delves into the ethical considerations surrounding the limitation of life support in nursing, emphasizing the critical role of ethical principles in healthcare decision-making. It examines a case study where a patient with a DNR order experiences respiratory failure, prompting a discussion on patient autonomy, beneficence, non-maleficence, and justice. The essay highlights the importance of adhering to patient wishes, ensuring quality of life, and navigating the complexities of withdrawing or withholding life-sustaining treatments. It underscores the legal and ethical obligations of healthcare providers to provide optimal care while respecting patient autonomy and the ethical implications of decisions regarding end-of-life care. The essay references several scholarly articles to support its arguments, providing a comprehensive analysis of the ethical dilemmas faced by nurses in end-of-life situations.