This nursing assignment analyzes the post-operative care of a 76-year-old man, Mr. Frank Wright, who underwent a total knee replacement. The report prioritizes nursing interventions within the first 24 hours, including the management of blood loss, pain, and wound care. It addresses the use of blood transfusions, cryotherapy, and medication. The assignment also examines the impact of patient comorbidities such as hypertension, smoking, and obstructive sleep apnea on recovery, and discusses associated nursing interventions. Finally, it outlines the discharge planning, including patient education on lifestyle modifications, smoking cessation, and referrals to specialists like cardiologists, orthopedists, and occupational therapists. The report emphasizes the importance of clinical reasoning, patient monitoring, and holistic care in the surgical setting.