Organ-on-Chips Technology: A Comprehensive Analysis of the Technology

This essay provides a comprehensive overview of organ-on-chips technology. It defines the technology as a microfluidic cell chip that simulates the activities and physiological responses of complete organs. The essay explores the working principles, which involve organ chips, software applications, and instrumentation. It highlights the advantages, such as speeding up research and providing more accurate results, and also discusses the drawbacks, including the dominance of surface effects and complexities in design. The essay concludes that organ-on-chip technology is valuable for identifying the impact of medicines and chemicals on the human body and it also discusses the features of the organ on chips and the advantages and disadvantages are also explained.

Organ-on-chips technology

ORGAN-ON-CHIPS TECHNOLOGY
1
Organ-on-chips technology
The organ on the chip is defined as a technology that offers an alternative animal
testing process where each individual chip is composed of a clear flexible polymer about
the size of a computer memory stick (Elveflow, 2018). It is the multi-channel 3D
microfluidic cell chip which simulates the activities and physiological response of the
complete organs. The aim of this essay is to understand the concept of the organ on chip
technology with their features. This essay will describe the phenomena of the organ oh
a chip with their working principle and advantages and disadvantages of this
technology.
Organs on the chip are an advanced technology which is developed on the micro-
contrived chips that size is around AA battery. It has the ability to assist researchers to
gain a well sympathetic of the impact of the drugs, infection bacteria in nutrients and
additional damaging materials on the consumer body system (Emulate bio, 2016).
There are major 3 mechanisms of this technology, for example, organ chips, software
applications, and instrumentation. The organ chips are developed to re-form the usual
makeup and motorized forces which cell experiences in the individual’s body system.
These chips are linked with the individual’s cells and their tiny fluidic channels produce
the blood in the consumer body system. In which the size of each organ chip is around
AA battery and they are more flexible to recreate the breathing motions.
The instrumentations are developed for recreating the consumer body’s living
process which involves the flow of blood and breathing movement. In several cases, the
organ chips are connected with each other so that researcher can observe how the
various organ systems interact with each other (FDA, 2018). During the software
application process, the researcher can extract data and information which can be
gathered and analyzed by using modern software. Such kind of software is developed to
provide the precise control and monitor of the organ system's living microenvironment.
It is observed that the software application has the capability to configure cell networks
and architecture, mechanical forces, and biochemical surroundings.
There are many advantages of this technology such as speeding up research,
more accurate and flexible rather than other, it is very easy to understand and use,

ORGAN-ON-CHIPS TECHNOLOGY
2
portable and the size of the organ on the chip is very small like AA battery (WYSS,
2018). Due to small size numbers of the microfluidic system can be integrated on single
money. It is analyzed that the microfluidic chips have few benefits as compared to the
other technologies.
Moreover, there are few drawbacks of this technology, for example, due to the
microfluidics dimension the surface impact widely dominates volume effects, very little
mixing at the time of laminar flow and not so portable. The fluids in the microfluidic the
Reynolds numbers will remain very less and it is very complex to design and implement.
Such kind of technology is allowed to create and generate numbers of microfluidic chips
which can simulate organ functions like lungs, gut, and liver. It also allows consumers
and health care industry to witness the side impact of the drugs on various organs but it
not limited to the treatment targets.
It is concluded that the organ on a chip technology is the best technology which
can be used to identify the impact of the medicines, chemical and other harmful
materials on the individual’s body. This essay is completely based on the organ on chip
technology and readers can enhance their knowledge in the area of the organ on chips.
In which the features of the organ on chips are discussed and the advantages and
disadvantages are also explained.

ORGAN-ON-CHIPS TECHNOLOGY
3
References
Elveflow (2018). INTRODUCING ORGANS ON CHIP, Retrieved from:
https://www.elveflow.com/organs-on-chip/organs-chip-review/
Emulate bio (2016). Organs-on-Chips , Retrieved from: https://emulatebio.com/organs-
on-chips/
FDA (2018). ORGANS-ON-CHIPS TECHNOLOGY, Retrieved from:
https://www.fda.gov/downloads/Food/FoodScienceResearch/UCM551309.pdf
WYSS (2018). Introduction to Organs-on-a-Chip, Retrieved from:
https://wyss.harvard.edu/media-post/introduction-to-organs-on-a-chip/