This report presents a comprehensive clinical update on Parkinson's Disease, a progressive neurodegenerative disorder. It begins with an introduction to the disease, its prevalence, and the five identified stages. The report details the aetiology and pathophysiology, including the role of dopamine reduction, genetic mutations (LRRK2, GBA, SNCA), and environmental factors. It outlines the progression of the disease according to Braak’s hypothesis, touching upon non-motor symptoms like hyposmia and constipation. Diagnostic methods, including SPECT scans, MRI, CT scans, and pathological tests, are discussed alongside the use of the Optimised Cuttlefish Algorithm. The clinical manifestations, prognosis, and treatment procedures, including pharmacological interventions like Carbidopa-Levodopa, dopamine agonists, MAO-B inhibitors, and surgical procedures like deep brain stimulation, are thoroughly examined. The report also addresses public health implications, such as reducing pesticide use and promoting omega-3 fatty acid intake. The conclusion summarizes the key findings and emphasizes the importance of early intervention.