This scientific report provides a comparative analysis of Pertussis, Diphtheria, and HIB, three common infectious airborne diseases, primarily affecting infants. The report explores the etiology and morphology of the causative agents, including Corynebacterium diphtheriae and Bordetella pertussis, as well as the epidemiology, incidence, and prevalence of each disease. It delves into the pathophysiology, clinical manifestations, and distinct characteristics of each infection, such as the meningitis associated with Hib. The report further examines the natural history, modes of transmission, and diagnostic methods, including provisional and definitive diagnoses. It also discusses the treatment and management strategies, including pharmacokinetics, pharmacodynamics, and potential adverse effects of medications like ampicillin and macrolide antibiotics. The report highlights the importance of vaccination and the impact of these diseases on public health, referencing data from Australia and other regions.