NSC2500 Pharmacology Presentation: Cancer Pathophysiology and Drugs

This presentation provides a comprehensive overview of pharmacology, specifically focusing on cancer treatment. It delves into the pathophysiology of cancer, highlighting the role of factors like insulin and adinopectin in energy balance disruption and the impact of mutations in p53 genes. The presentation details the use of Adriamycin (doxorubicin) as a key drug, its mode of action involving intercalation and topoisomerase inhibition, and its pharmacokinetic properties, including a half-life of 24-48 hours. Furthermore, it acknowledges the drug's side effects and emphasizes the importance of nursing practices, such as formulating care plans and establishing therapeutic relationships, to support patients physically and mentally. The presentation underscores the need for patient-centered care to improve the overall health conditions of women globally. This assignment is designed to improve the knowledge of homeostasis and how disruption may lead to a specific disease or disorder. It also helps students understand how drug therapies address a particular pathophysiology, identify drug mode of action, indications, contraindications, potential interactions, adverse effects and therapeutic outcomes.

Running head: PHARMACOLOGY
Topic: PHARMACOLOGY
Name of the Student:
Name of the University:
Author Note:

1PHARMACOLOGY
Abstract
There has been a wide prevalence of cancer as the major disease all over the world. Non
hormonal cancers are usually defined as those cancers where the expression of the cancer
cells are not affected by the hormones like estrogen, progesterone as well as epidermal
growth factors. According to the statistical reports of the World Health Organization, almost
15 % of the breast cancers are triple negative. The energy balance of the human body during
the diseases is affected by the compounds insulin, adinopectin, which are considered as the
pivotal factors regarding the homeostasis in the human body. There are various
pathophysiogical factors of the diseases which involve the development of visceral
metastasis, symptoms like proliferation of cellular fibrosis. Mutations in the p53 genes are
also involved in the symptoms of the diseases. For the effective treatment of the disease,
Adriamycin is used. It is also known as doxorubicin. Structurally the drug usually belongs to
the class of the anthracyclines. The pivotal mode of action for the drug is through intravenous
routes. Regarding the mode of action, it is often involved in the intercalation, inhibition of the
enzyme known as topoisomerase. Half-life of the drug is usually 24-48 hours considering the
pharmacokinetics of the drug. Although the drug is very effective, it has several side effects
like vomiting, nausea and redness of the eyes. Various nursing practices are involved with the
effective management of the disease. Formulation of an effective care plan along with
establishment of stable therapeutic relationship is required for providing care and support to
the patients. The patient suffering from cancer need mental as well as physical care through
an effective patient centred effort. Thus consideration of these factors would lead to an
enhancement of the total health condition of women across the world.