Chemistry Report: Reservoir-Based Polymer Drug Delivery Systems

This report provides a comprehensive overview of reservoir-based polymer drug delivery systems. It begins by highlighting the limitations of conventional drug delivery methods, such as systemic side effects and the need for frequent administration, which have spurred the development of advanced drug delivery systems. The report then classifies polymer-based drug delivery systems into three types: reservoir-based systems, polymer drug conjugate systems, and monolithic matrix systems, with a specific focus on reservoir-based systems. Reservoir-based systems, which involve a polymer coating enclosing a drug core, are discussed in detail, including their applications for long-term drug depots and localized administration. The report explores the various polymers used in these systems, such as PBMA, PEVA, and phosphorylcholine, and categorizes reservoir-based systems based on their morphology, including nanospheres, microspheres, and hydrogel systems. The report also discusses the use of implants and smart polymers for drug delivery. The report concludes by emphasizing the importance of precise drug delivery and highlights the need for future advancements, such as systems that can detect disease indicators and monitor drug release rates, as well as improvements in drug loading capacity. The report references key studies and findings in the field.