This research report investigates the role of Popeye domain-containing (POPDC) proteins in cancer progression, focusing on their potential as therapeutic targets. The study examines the structure, function, and roles of POPDC proteins (POPDC1, POPDC2, and POPDC3) in various cancers, including breast, gastric, hepatocellular, and colorectal carcinoma. It highlights how suppression of POPDC proteins is associated with increased malignancy and explores strategies for targeting the Popeye domain, a unique cAMP binding motif, for drug development. The methodology involves analyzing existing research and in vitro models like FRET assays to understand the impact of POPDC protein modulation on cancer cell behavior. The report concludes that the lack of specific drugs targeting POPDC proteins presents an opportunity for further research into their viability as drug targets, recommending investigations into drugs that disrupt POPDC protein function and target their extracellular domain.
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