This nursing assignment focuses on the post-operative care of a 76-year-old man who underwent a right total knee replacement. It begins with an introduction to post-operative care, emphasizing the importance of a comprehensive care plan to prevent complications. Part A details the patient's condition, including altered vital signs and medications, and discusses the clinical issues of infection risk, impaired physical mobility, and acute pain, along with relevant nursing interventions and rationales. Part B addresses the impact of smoking in the post-operative period, particularly the risks associated with anesthesia, hypertension, cardiovascular problems, and obstructive sleep apnea. It highlights the crucial role of nursing interventions in monitoring, educating, and preventing further deterioration. Part C outlines the discharge plan, including medication management, activities of daily living, physical therapy, diet, and psychological support. The conclusion summarizes the significance of a well-structured care plan in minimizing post-operative complications and promoting patient recovery. This report demonstrates the application of nursing knowledge, clinical decision-making, and evidence-based practice in the care of a surgical patient.