This report delves into evidence-based nursing practices within the context of post-operative care, using a case study of a 45-year-old patient, Kathleen Johnson, who underwent sleeve gastrectomy surgery. Kathleen, suffering from morbid obesity, type 2 diabetes, and other stressors, presented with post-operative complications including shortness of breath, high blood pressure, and low urine output, potentially indicating acute kidney injury. The report explores the aetiology and pathophysiology of obesity and type 2 diabetes, linking them to Kathleen's condition and the surgical procedure. It then examines the underlying pathophysiology of her post-operative deterioration, detailing the importance of proper airway management, pain assessment, and monitoring for bleeding and infection. The report also justifies the involvement of an interdisciplinary healthcare team, including a dietician, critical care pharmacist, and respiratory therapist, to optimize patient outcomes. The conclusion emphasizes the significance of continuous monitoring and comprehensive care in improving patient health.