This report delves into the critical aspects of pressure area care (PAC), emphasizing evidence-based practices to ensure patient safety and well-being. It begins by highlighting the three pillars of evidence-based practice: patient values, clinical expertise, and relevant research. The report then examines systematic reviews as a crucial tool for gathering unbiased knowledge and establishing best practice policies. Key concepts such as incidence, prevalence, morbidity, and mortality related to pressure injuries are thoroughly discussed, with statistical data from Australia provided to illustrate the scope of the issue. Furthermore, the report explores the characteristics of Randomized Controlled Trials (RCTs) and their significance in understanding the effectiveness of various treatments. The report underscores the importance of PAC in the context of nursing care and the need for nurses to stay informed on the latest evidence-based approaches to enhance patient outcomes. The report also provides an overview of the NMBA Codes of Conduct for Midwives and Nurses (2018), which state that “Nurses provide safe, person-centred, evidence-based practice for the health and wellbeing of people (pp.6 & 7). In addition, the NMBA Standards for Practice for Registered Nurses and Midwives specifies that nurses and midwives must “access, analyse, and use the best available evidence that includes research findings, for safe, quality practice” (pp.3 & 4).