This report presents a systematic review investigating the effectiveness of psychological interventions designed to minimize psychological distress in cancer patients. The research focuses on interventions such as Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT) within oncology units. The review, adhering to PRISMA guidelines, analyzed articles from databases like MEDLINE and PubMed, considering studies within the last ten years. The study included cancer patients of all age groups, comparing various interventions and assessing methodological quality using the AMSTAR tool. The findings highlight the positive outcomes of CBT and ACT in managing behavioral changes, distress, and anxiety. The review emphasizes the need for psychological interventions in oncology care to improve the quality of life for cancer patients, despite the need for further research to strengthen the evidence base.