This report examines the psychological factors contributing to physical illness, using the case of Zac who is facing job loss, stress, depression and substance use. The analysis explores the relationship between psychological factors and physical health, particularly focusing on the impact of stress, depression, and substance abuse (cocaine and alcohol) on well-being and physical health outcomes. The report references relevant literature to support the analysis, emphasizing how psychological issues can lead to physical problems and impact overall quality of life. It also highlights the potential health risks associated with substance use and psychological distress, such as heart problems and cancer, and the importance of addressing these factors to improve health outcomes. The report emphasizes the interconnectedness of psychological and physical health, underscoring the need for comprehensive approaches to patient care.