This essay delves into the significant connection between psychological stress and coronary heart disease (CHD), a leading global health concern. It emphasizes how stress, encompassing factors like socioeconomic conditions, personality traits, and negative emotions, contributes to CHD. The essay highlights the alarming statistics from the World Health Organization (WHO), illustrating the high mortality rates associated with cardiovascular diseases, particularly in low and middle-income countries where individuals often experience heightened psychological stress. It explores the various symptoms of CHD, such as shortness of breath, chest pain, and irregular heartbeats, and underscores the role of long-term psychological stress and depression as primary risk factors. The essay also examines the impact of stress on the heart rate, cardiac output, and blood pressure, emphasizing the need for identifying psychological causes to design effective rehabilitation programs. Furthermore, the essay discusses the impact of psychological stress on both physical and mental health, and the importance of managing stress to prevent or mitigate the risk of CHD. The role of social networks, the impact of emotions, and the potential for preventative measures are also discussed, stressing the link between mind and heart, and highlighting the need for further research in this area.