This nursing assignment critically examines quality and safety within the Australian healthcare system, focusing on the National Safety and Quality Health Service (NSQHS) Standards. The essay begins with a broad discussion of quality and safety, emphasizing the importance of patient satisfaction and outcomes, including mental and physical well-being, reduced costs, and increased patient awareness. It then selects NSQHS Standard 3, which addresses preventing and controlling hospital-acquired infections (HAIs), as the focal point. A clinical care activity, specifically the use of chlorhexidine-alcohol as a skin antiseptic to prevent catheter-related infections, is proposed and analyzed. The assignment utilizes the Donabedian model (structure, process, outcome) to assess the activity's effectiveness, highlighting the role of nursing professionals, proper techniques, and patient education. The essay concludes that such clinical care activities significantly improve patient safety and healthcare standards by reducing HAIs, thereby decreasing hospital stays and associated costs, ultimately enhancing patient satisfaction.