This sociology essay examines racism as a significant social determinant of health for Aboriginal and Torres Strait Islander peoples in Australia. It argues that racism leads to unfair distribution of opportunities and wealth, contributing to health disparities. The essay discusses the impact of racism, the historical and contemporary challenges faced by Indigenous Australians, and the role of leaders like Joyce Clague in advocating for Indigenous rights and fighting against discrimination. Furthermore, it highlights the crucial role of registered nurses in addressing healthcare inequalities by providing culturally safe care, implementing upstream strategies, and promoting education to combat prejudice and improve the health outcomes of Aboriginal communities. The conclusion emphasizes the importance of equity in healthcare and the need for appropriate nursing interventions to support disadvantaged Indigenous Australians.