This report investigates the interrelationship between obesity and depression in adults, highlighting the increased risk of various diseases, including cardiovascular issues. The study explores the lack of established treatment models and the psychological burden associated with obesity, with statistics indicating a significant percentage of adults suffering from depression due to this condition. It examines the research question of identifying the best treatment for reducing depression in adults with obesity, emphasizing the importance of patient-centered care and addressing the impact of weight on psychological well-being. The methodology involves reviewing medical sources, conducting phone screenings, and implementing cognitive and behavioral approaches. The results reveal a strong correlation between BMI and mood disorders, with specific diagnostic conditions related to obesity. Prevention strategies, including dietary therapy, lifestyle modifications, and therapies like cognitive behavioral therapy, are discussed. The report also addresses the challenges faced by adults with obesity, such as social stigma and the impact of environmental factors on their psychological state. The aim is to determine effective treatments for depression in adults with obesity by analyzing the issues faced by adults with obesity and examining the ways or treatment for reducing depression in adult with obesity.