This essay delves into key historical periods from 1450 to 1650, examining the Renaissance, Reformation, and Scientific Revolution, and their interconnectedness with European colonialism. The essay begins by analyzing how Renaissance artists and intellectuals reconciled humanism with the dominance of the Roman Catholic Church and the feudal system. It then explores the ways in which Renaissance thinking foreshadowed the Protestant Reformation, highlighting the role of humanists and textual analysis. The essay further discusses the Scientific Revolution as an extension of the Renaissance, outlining the shift in scientific views and methods. Finally, it critically assesses the hypocrisy inherent in Europe's colonial settlements, contrasting them with the core principles of the Renaissance. The essay utilizes academic sources to support its arguments, providing a comprehensive overview of these pivotal historical events.